The galactosyl moiety of brain cerebrosides

The galactosyl moiety of brain cerebrosides.

Thirteen years ago I found that galactosyl ceramide undergoes metabolic conversion in the brain of young ratsa). Month-old rats were injected with 14C-galactose, rats were sacrificed at various intervals, and the brain lipids were fractionated according to the following scheme (fig. 1). The radioactivity in the galactose of each lipid group is shown in fig. 2, which plots total activity against...

Preparative isolation of cerebrosides (galactosyl and glucosyl ceramide).

An improved method for isolating cerebrosides from natural sources is described. The method is particularly suited to large scale work and can be adapted to the isolation of sphingolipids that are less polar than the gangliosides. It is based on the use of sodium sulfate to absorb the water from chloroform-methanol tissue extracts, the use of triiodide to cleave the ether linkage of plasmalogen...

On the Cerebrosides of the Brain Tissue

Under the general name of cerebrosides have been described a number of individual substances designated by special names and apparently possessing distinct chemical and physical properties. The exact relationship of the substances one to another has not been fully established. The subject has been treated in a critical way in several exhaustive articles written by men as competent as Frankel,l ...

Lxxxvii. the Methylation of the Cerebrosides of Ox Brain

The Nature of the Sugar Residue of the Cerebrosides of Ox-Brain.